Important Information to Know About Connective Tissue Cancer (Sarcoma) What is Sarcoma?

Sarcoma is a rare type of cancer that makes up only 1% of all cancers. It develops from cells in connective tissues, which are essential components of the body's structures, including bones, muscles, fat, blood vessels, and other connective tissues.

There are over 80 subtypes of sarcoma, each exhibiting different growth characteristics and responses to treatment, such as:

• Leiomyosarcoma – cancer arising from muscle cells

• Liposarcoma – cancer arising from fat cells

• Osteosarcoma – cancer arising from bone cells

Causes of Connective Tissue Cancer

The exact cause of sarcoma remains unclear and is often not attributed to external factors. Most cases arise from mutations in the body’s cells that lead to abnormal division and, ultimately, to cancer.

Genetic factors may sometimes contribute, such as gene abnormalities that regulate cell division. Individuals with these genetic abnormalities may face an increased risk of developing sarcoma from a young age.

Common Locations for Connective Tissue Cancer

Sarcoma can occur anywhere in the body but is most commonly found in: 

• Limbs – the most common site and easiest to detect 

• Abdomen and thorax – more difficult to detect; symptoms often only appear when the mass is large.

If cancer develops in hard-to-detect locations, such as the abdomen or thorax, symptoms may not emerge until the mass is large or has spread to other organs.